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, Christopher J De Jonge University of Minnesota Medical Center, Department of Urology, University of Minnesota , Minneapolis, MN, USA Search for other works by this author on: Oxford Academic Christopher L R Barratt Division of Systems Medicine, School of Medicine, Ninewells Hospital and Medical School, University of Dundee , Dundee, UK Search for other works by this author on: Oxford Academic R John Aitken Discipline of Biological Sciences, School of Environment and Life Sciences, College of Engineering, Science and Environment, University of Newcastle , Newcastle, Australia Search for other works by this author on: Oxford Academic Richard A Anderson MRC Centre for Reproductive Health, University of Edinburgh , Edinburgh, UK Search for other works by this author on: Oxford Academic Peter Baker Global Action on Mens Health , UK Search for other works by this author on: Oxford Academic David Y L Chan Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin , Hong Kong SAR, NT, The People's Republic of China Search for other works by this author on: Oxford Academic Mark P Connolly Health Economics, Global Market Access Solutions LLC , Mooresville, NC, USA University Medical Center Groningen , Groningen, Netherlands Search for other works by this author on: Oxford Academic Michael L Eisenberg Department of Urology and Obstetrics & Gynecology, Stanford University , Stanford, CA, USA Search for other works by this author on: Oxford Academic Nicolas Garrido IVIRMA Global Research Alliance, IVI Foundation , Instituto de Investigación Sanitaria La Fe (IIS La Fe), Valencia, Spain Search for other works by this author on: Oxford Academic Niels Jørgensen Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , Copenhagen, Denmark Search for other works by this author on: Oxford Academic
, Sarah Kimmins Department of Pharmacology and Therapeutics, Faculty of Medicine, McGill University , Montreal, QC, Canada The Centre de Recherche du Centre Hospitalier de l'Université de Montréal , Montréal, QC, Canada The Département de Pathologie et Biologie Cellulaire, Université de Montréal , Montréal, QC, Canada Search for other works by this author on: Oxford Academic Csilla Krausz Department of Experimental and Clinical Biomedical Sciences, ‘Mario Serio’, University of Florence, University Hospital of Careggi (AOUC) Florence , Italy Search for other works by this author on: Oxford Academic Robert I McLachlan Hudson Institute of Medical Research and the Department of Obstetrics and Gynaecology, Monash University, Melbourne, Australia. Monash IVF Group , Cremorne, Australia Search for other works by this author on: Oxford Academic Craig Niederberger Clarence C. Department of Urology, University of Illinois Chicago (UIC), College of Medicine, Department of Bioengineering, UIC College of Engineering , Chicago, IL, USA Search for other works by this author on: Oxford Academic Moira K ÓBryan School of BioSciences and Bio21 Institute, The University of Melbourne , Parkville, Australia Search for other works by this author on: Oxford Academic Allan Pacey Faculty of Biology, Medicine and Health, Core Technology Facility, University of Manchester , Manchester, UK Search for other works by this author on: Oxford Academic Lærke Priskorn Department of Growth and Reproduction and International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health (EDMaRC), Rigshospitalet, University of Copenhagen , Copenhagen, Denmark Search for other works by this author on: Oxford Academic Satu Rautakallio-Hokkanen Fertility Europe , Evere, Belgium Search for other works by this author on: Oxford Academic Gamal Serour The International Islamic Center for Population Studies and Research, Al-Azhar University and the Egyptian IVF Center , Maadi, Cairo, Egypt Search for other works by this author on: Oxford Academic Joris A Veltman Biosciences Institute, Faculty of Medical Sciences, Newcastle University , Newcastle upon Tyne, UK Search for other works by this author on: Oxford Academic Donna L Vogel School of Medicine, Johns Hopkins University , Baltimore, MD, USA Search for other works by this author on: Oxford Academic Mónica H Vazquez-Levin Instituto de Biología y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas de Argentina—Fundación IBYME , Buenos Aires, Argentina Corresponding author: Mónica H. Vazquez-Levin, PhD. Instituto de Biología y Medicina Experimental. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET). Fundación IBYME (FIBYME). Vuelta de Obligado 2490 (C1428ADN) Buenos Aires, Argentina. Phone: (5411) 4783-2869 ext 1248 & 1271 Fax: (5411) 4786-2564; mobile: 5491141729427. E-mail 1: mhvazquez@ibyme.conicet.gov.ar E-mail 2: mhvazl@gmail.com Search for other works by this author on: Oxford Academic
Human Reproduction Open, hoae017, https://doi.org/10.1093/hropen/hoae017
Published:
12 April 2024
Article history
Received:
08 September 2023
Revision received:
22 February 2024
Editorial decision:
11 March 2024
Published:
12 April 2024
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Christopher J De Jonge, Christopher L R Barratt, R John Aitken, Richard A Anderson, Peter Baker, David Y L Chan, Mark P Connolly, Michael L Eisenberg, Nicolas Garrido, Niels Jørgensen, Sarah Kimmins, Csilla Krausz, Robert I McLachlan, Craig Niederberger, Moira K ÓBryan, Allan Pacey, Lærke Priskorn, Satu Rautakallio-Hokkanen, Gamal Serour, Joris A Veltman, Donna L Vogel, Mónica H Vazquez-Levin, Current global status of male reproductive health, Human Reproduction Open, 2024;, hoae017, https://doi.org/10.1093/hropen/hoae017
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Abstract
BACKGROUND
The widespread interest in male reproductive health (MRH), fueled by emerging evidence, such as the global decline in sperm counts, has intensified concerns about the status of MRH. Consequently, there is a pressing requirement for a strategic, systematic approach to identify critical questions, collect pertinent information, and utilize this data to develop evidence-based strategies. The methods for addressing these questions and the pathways towards their answers will inevitably vary based on the variations in cultural, geopolitical, and health-related contexts. To address these issues, a conjoint ESHRE and Male Reproductive Health Initiative (MRHI) Campus workshop was convened.
OBJECTIVE AND RATIONALE
The three objectives were: first, to assess the current state of MRH around the world; second, to identify some of the key gaps in knowledge; and, third, to examine how MRH stakeholders can collaboratively generate intelligent and effective paths forward.
SEARCH METHODS
Each expert reviewed and summarized the current literature that was subsequently used to provide a comprehensive overview of challenges related to MRH.
OUTCOMES
This narrative report is an overview of the data, opinions and arguments presented during the workshop. A number of outcomes are presented and can be summarized by the following overarching themes: MRH is a serious global issue and there is a plethora of gaps in our understanding; there is a need for widespread international collaborative networks to undertake multidisciplinary research into fundamental issues, such as lifestyle/environmental exposure studies, and high quality clincial trials; and there is an urgent requirement for effective strategies to educate young people and the general public to safeguard and improve MRH across diverse population demographics and resources.
LIMITATIONS, REASONS FOR CAUTION
This was a workshop where worldwide leading experts from a wide range of disciplines presented and discussed the evidence regarding challenges related to MRH. Whilst each expert summarised the current literature and placed it in context, the data in a number of areas is limited and/or sparse. Equally, important areas for consideration may have been missed. Moreover, there are clear gaps in our knowledge base, which makes some conclusions necessarily speculative and warranting of further study.
WIDER IMPLICATIONS
Poor MRH is a global issue that suffers from low awareness among the public, patients and heathcare professionals. Addressing this will require a coordinated multidisciplinary approach. Addressing the significant number of knowledge gaps will require policy makers prioritizing MRH and its funding.
STUDY FUNDING/COMPETING INTEREST(S)
The authors extend their gratitude to ESHRE for financial support of the Budapest Campus Workshop. PB is the Director of the not-for-profit organization Global Action on Men’s Health and receives fees and expenses for his work, (which includes the preparation of this manuscript. Conflicts of interest: CJDJ, CLRB, RAA, PB, MPC, MLE, NG, NJ, CK, AAP, MKO, SR-H, MHV-L: ESHRE Campus Workshop 2022 (Travel support—personal). CJDJ: Cambridge University Press (book royalties—personal). ESHRE Annual Meeting 2022 and Yale University Panel Meeting 2023 (Travel support—personal). CLRB: Ferring and IBSA (Lecture), RBMO editor (Honorarium to support travel etc), ExSeed and ExScentia (University of Dundee), Bill & Melinda Gates Foundation (for research on contraception). MPC: Previously received funding from pharmaceutical companies for health economic research. The funding was not in relation to this work and had no bearing on the contents of this work. No funding from other sources has been provided in relation to this work (Funding was provided to his company Global Market Access Solutions. MLE: Advisor to Ro, Doveras, Next, Hannah, Sandstone CK: European Academy of Andrology (Past president UNPAID), SK: CEO of His Turn, a male fertility Diagnostic and Therapeutic company (No payments or profits to date). RIM: www.healthymale.org.au (Australian Government funded not for profit in men’s health sector (Employed as Medical Director 0.2 FET), Monash IVF Pty Ltd (Equity holder). NJ: Merck (consulting fees), Gedeon Richter (honoraria). SR-H: ESHRE (Travel reimbursem*nts). CN: LLC (Nursing educator); COMMIT (Core Outcomes Measures for Infertility Trials) Advisor, meeting attendee and co‐author; COMMA (Core Outcomes in Menopause) Meeting attendee and co‐author; International Federation of Gynecology and Obstetrics (FIGO) Delegate Letters and Sciences; ReproNovo, Advisory board; American Board of Urology Examiner; American Urological Association Journal subsection editor, committee member, guidelines co‐author Ferring Scientific trial NexHand Chief Technology Officer, stock ownership Posterity Health Board member, stock ownership. AP: Economic and Social Research Council (A collaborator on research grant number ES/W001381/1). Member of an advisory committee for Merck Serono (November 2022), Member of an advisory board for Exceed Health, Speaker fees for educational events organized by Mealis Group; Chairman of the Cryos External Scientific Advisory Committee: All fees associated with this are paid to his former employer The University of Sheffield. Trustee of the Progress Educational Trust (Unpaid). MKO’B: National Health and Medical Research Council and Australian Research Council (Funding for research of the topic of male fertility), Bill and Melinda Gates Foundation (Funding aimed at the development of male gamete-based contraception), Medical Research Future Fund (Funding aimed at defining the long-term consequences of male infertility). MHV-L: Department of Sexual and Reproductive Health and Research (SRH)/Human Reproduction Programme (HRP) Research Project Panel RP2/WHO Review Member; MRHI (Core Group Member), COMMIT (member) EGOI (Member); Human Reproduction (Editor), Fertility and Sterility (Editor), AndroLATAM (Founder and Coordinator).
Lay Summary
WHAT DOES THIS MEAN FOR PATIENTS?
There is a growing interest in men's reproductive health because of new evidence showing a decline in sperm counts worldwide. Researchers have found links between poor reproductive health in men and other health problems. They are also looking into how a father's health can affect their children's well-being. To tackle these issues, the European Society for Human Reproduction and Embryology and the Male Reproductive Health Initiative organized an international workshop. The goals were to assess the current state of men's reproductive health globally, pinpoint knowledge gaps, and come up with plans for the future. This report summarizes the information, opinions, and discussions from the workshop. The main takeaways are that men's reproductive health is a serious global concern and there is a lot we still do not understand. The report emphasizes the need for international collaborations to study important issues like the impact of lifestyle and environmental factors. It also highlights the urgency of finding effective ways to reinforce education about how to protect and improve men's reproductive health across different demographics (for example age, race) and resources. To complement this analysis, we have recently published a practical plan, based on the evidence, to guide us in moving forward. This plan emphasizes the importance of everyone around the world working together to make men's reproductive health a top priority.
male infertility, male reproductive health, andrology, fertility, contraception, genetics, epigenetics, education, economics, policy
Accepted manuscripts
Accepted manuscripts are PDF versions of the author’s final manuscript, as accepted for publication by the journal but prior to copyediting or typesetting. They can be cited using the author(s), article title, journal title, year of online publication, and DOI. They will be replaced by the final typeset articles, which may therefore contain changes. The DOI will remain the same throughout.
This content is only available as a PDF.
© The Author(s) 2024. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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